Magnesium Sulfate Before Preterm Birth for Neuroprotection An Updated Cochrane Systematic Review
Subspecialty: Neurovascular
Type: Clinical Summary
### Key Findings - **Reduction of Cerebral Palsy:** Magnesium sulfate significantly reduces the risk of cerebral palsy in infants compared to placebo (risk ratio [RR] 0.71, 95% CI 0.57–0.89). - **Reduction of Combined Outcomes:** Use of magnesium sulfate decreases the risk of death or cerebral palsy (RR 0.87, 95% CI 0.77–0.98). - **Effects on Mortality:** There was little to no difference in overall mortality rates (RR 0.96, 95% CI 0.82–1.13) among children and data on major neurodevelopmental disability indicated no significant benefit (RR 1.09, 95% CI 0.83–1.44). - **Adverse Effects in Mothe…