SDR for Hereditary Spastic Paraplegia (HSP)

Subspecialty: Functional

Type: Clinical Summary

Hereditary Spastic Paraplegia (HSP) is a genetically heterogeneous, predominantly lower‑limb‑predominant neurodegenerative disorder caused by distal axonal degeneration of the corticospinal tracts, producing progressive spasticity and weakness. This review reports a single-center series of 37 patients who underwent Selective Dorsal Rhizotomy (SDR) for HSP-associated spasticity (1988–2021) and summarizes patient selection, surgical technique, safety, outcomes, and practical guidance for clinicians considering SDR in HSP. Overview The series includes 37 children and adults with genetically or cl…

Source Papers

Selective Dorsal Rhizotomy for Treatment of Hereditary Spastic Paraplegia-Associated Spasticity in 37 Patients. (2021)
Hereditary Spastic Paraplegia: An Update. (2022)
Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia. (2022)
Dorsal Rhizotomy in Children with Hereditary Spastic Paraplegia. (2026)