Genetics and molecular mechanisms of craniosynostosis
Subspecialty: Craniofacial surgery
Type: Clinical Summary
Craniosynostosis is a congenital disorder defined by premature fusion of one or more cranial sutures, disrupting the coordinated growth of skull and brain and driven by genetic, molecular and environmental factors. This review summarizes the clinical phenotypes and complications of craniosynostosis, the developmental and molecular mechanisms (including suture mesenchymal stem cell loss and dysregulated signaling pathways), and current surgical management plus emerging biological therapies such as mesenchymal stem cell-based suture regeneration. Overview Craniosynostosis affects between 1 in 21…