Cluster Headache
Subspecialty: Neurology
Type: Clinical Summary
Cluster headache is a primary headache disorder characterized by strictly unilateral, severe orbital/supraorbital/temporal pain with ipsilateral cranial autonomic features driven by activation of trigeminal nociceptive pathways and the cranial parasympathetic (trigeminal–autonomic) reflex. This review and guideline synthesis summarize diagnostic criteria, recommended investigations to exclude secondary causes, evidence-based acute and preventive therapies (including pharmacological, nerve block, neuromodulation and emerging CGRP‑targeted options), and practical monitoring requirements for clin…
Source Papers
- Managing cluster headache (2019)
- European Academy of Neurology guidelines on the treatment of cluster headache. (2023)